The p15INK4b/p16INK4a/RB1 Pathway Is Frequently Deregulated in Human Pituitary Adenomas
نویسندگان
چکیده
منابع مشابه
MicroRNAs in Human Pituitary Adenomas
MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. Emerging evidence indicates that miRNAs are dysregulated in pituitary adenomas, a class of intracranial neoplasms which account for 10-15% of diagnosed brain ...
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Protein tyrosine nitration is an important reactive oxygen species/reactive nitrogen species (ROS/RNS)-related modification that is derived from the main in vivo peroxynitrite pathway and the secondary myeloperoxidase reaction pathway (Scaloni, 2006, Khan et al., 1998, Zhan & Desiderio, 2009a, 2009b, and 2009c, Dalle-Donne et al., 2005, Zhan, Wang, & Desiderio, 2013). Tyrosine nitration adds an...
متن کاملExpression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course.
Pituitary ademonas are benign tumours with different biological behaviour, especially with regard to tumour size, invasion, endocrine function, intratumour cystic lesion and apoplexy. There is little understanding of the growth and the control of progression of pituitary tumours. In the present study, we investigated the expression of mammalian target of rapamycin (mTOR) pathway regulators, in ...
متن کاملHuman kallikrein 10 in surgically removed human pituitary adenomas.
OBJECTIVE Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth. In this work, we investigated KLK10 immunoexpression in various types of surgically removed human pituitary tumors. DESIGN Specimens were fixed in formalin and embedded in paraffin. Immunostaining was performed by the streptavidin-biotin-pe...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2005
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/64.5.398